An enzyme in the human digestive system that’s been blamed for causing an alarming spike in the incidence of cancer is being linked to the development of cancer in lab animals, a study has found.
In a study of nearly 40,000 human samples, researchers identified a genetic variant that makes it harder for certain enzyme proteins to break down carbohydrates, which in turn causes cancer.
The study, published in the Proceedings of the National Academy of Sciences, found that the enzyme changes in the digestive system may play a role in the development and spread of a range of cancers including non-Hodgkin lymphoma, liver cancer and pancreatic cancer.
Scientists were not able to determine the exact cause of the changes in human digestive systems, but their findings could provide a potential explanation for why some people are more likely to develop cancer.
“It may be possible that the observed associations with the observed changes in intestinal microbial communities may be caused by an increased prevalence of these cancers in populations where these changes occur,” the researchers wrote in their study.
“We believe that these changes are likely to be related to a common and highly prevalent genetic variant in human population.”
The researchers found that there was a clear association between a genetic variation known as CHEM5A1 and the development or spread of pancreatic and non-Liver cancers.CHEM5a1, which is linked to liver cancer, was also linked to lung and stomach cancer.
They found that CHEM-5a2 was found to be linked to pancreatic, non-liver, lung and colorectal cancer, although the findings of the study did not include data for pancreatic cancers.
The new study was one of several that have examined the role of this particular enzyme in human health.
A 2016 study published in Science also linked the enzyme to the progression of lung cancer, but it did not link CHEM2 to the same disease.
A number of other studies have linked it to breast cancer, colon cancer and prostate cancer.
In its 2016 study, the American Cancer Society said the enzyme has been linked to a range “of cancers and other conditions, including colon, breast, lung, cervical, pancreatic-associated and other cancers”.
The CHEM3A mutation has been associated with a wide range of cancer-causing mutations including leukemia, glioma and thyroid cancer.
But the findings from the latest study, which included almost 20,000 samples from around the world, may provide a more definitive explanation for the link between this enzyme and cancer.
Researchers in the US looked at more than 100 studies on the CHEM7 gene, and found that a mutation in this gene linked with pancreatic tumors.
The CHM5A mutation appears to be associated with pancreatitis, a rare form of pancreatitis that’s caused by mutations in the CHM7 gene.
Scientists said the finding suggests the CHG7 mutation could be a key factor in the cancer-inducing properties of some enzymes, but that it is not known whether the mutations are associated with specific types of pancreatal cancers.
“While the mechanism(s) underlying the observed association between the CHMG7A1 mutation and pancreatitis are still unclear, we propose that the mutations may act through their interactions with a variety of other cancer-promoting enzymes,” the authors wrote in the study.
A spokesperson for the American Institute for Cancer Research said the new study did “not prove that the CHGV7A mutation is a risk factor for pancreatitis”.
“We know that it’s associated with the development, spread and progression of pancreatico-pancreatic cancers, but this does not mean that the mutation itself is a cause of these tumors,” the spokesperson said.
Topics:cancer,food-and-cooking,science-and_technology,sciences,health,nutrition,lifestyle-andness,health-policy,cancer,united-statesFirst posted April 15, 2020 08:58:53Contact Rebecca LaceyMore stories from Western Australia